Androgenetic alopecia (AGA) is a nonscarring progressive miniaturization of the hair follicle with a usually characteristic pattern distribution of hair loss in genetically predisposed men and women. Individuals with higher genetic predisposition to hair loss, start losing their hair earlier and to a greater degree than those with a lesser predisposition. By the age of 25, approximately 20% of men will shows the signs of hair loss which increases to 75% by the age of 60 years. Of the 75% of men, about half of these will show significant hair loss at frontal and vertex region. AGA affects up to 80% of men and 40% of women. Hair loss in women occurs usually post menopause, and they experience thinning of hair due to hair follicle’s genetic programming.
Minoxidil topical lotion and finasteride oral tablets are the Food and Drug Administration approved conservative treatment of hair loss. Minoxidil appears to prolong the anagen while finasteride is 5-alpha reductase Type II inhibitor which reduces the conversion of testosterone to dihydrotestosterone (DHT).
Platelet-rich plasma (PRP) proposed the benefits which included increase in hard and soft-tissue healing which is used in specialties such as orthopedics, sport medicine, diabetic ulcers, and plastic surgery. It became so widespread that it became effectively popular for joint problems, wound healing, and alopecia. After injecting PRP and MN, concentrated growth factor (CGF) was applied over the scalp which had growth factors, CD34+stem cells, leukocytes, and platelets which helps in the regeneration process.
Growth factors released from PRP which is a 1st generation platelet concentrate, may act on the stem cells in the bulge area of the follicles, stimulating the development of new follicles, and promoting neovascularization. Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) are important for hair formation and follicle size. PDGF plays a role in hair canal formation, while VEGF-mediated angiogenesis involvement is demonstrated in the control of hair growth and follicle size. PRP therapy is often used as a complementary solution for individuals undergoing hair transplant in Bangalore to enhance graft survival and overall results.
Administration of PRP and CGF has a positive effect on male pattern alopecia The following are the benefits:
- Administration of PRP and CGF attended a significant improvement in mean hair density, terminal hair density, mean anagen hairs, and telogen hairs.
- An increase in the anagen/telogen ratio
- Male sex and beginning of AGA after 25 years seem to respond better to the treatment.
- Hair fall also significantly reduced at the end of 6 months as compared before commencement of treatment.
Frequently Asked Questions (FAQs)
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